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the way you tell your story online can make all the difference. https://petrovlab-stanford.squarespace.com/news/congratulations-to-doran-and-katherine-on-their-recent-preprint-rnth3-zwem2-j64mr-mh267-nnkxh monthly 0.5 2024-07-01 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/8ea31783-c3d4-4f10-ac20-1c3af4cc77cf/Clare_Arecibo.jpg News - Clare Abreu is joining NYU Department of Biology as an Assistant Professor! - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://petrovlab-stanford.squarespace.com/news/congratulations-to-doran-and-katherine-on-their-recent-preprint-rnth3-zwem2-j64mr-mh267-dhx53-ty3g6-jecrr monthly 0.5 2024-06-22 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/01c75802-1dce-4a44-9f49-fab715cc6901/Screenshot+2024-06-22+at+10.14.20%E2%80%AFAM.png News - Grant Kinsler posts a biorxiv preprint on pleiotropy and modularity of adaptation - Make it stand out Whatever it is, the 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https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/645e85f9-305f-4b55-869d-7687d0dc471b/twitter-logo-black-png.png https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/d5c0e823-d265-4888-bc8e-4206281e56a9/mail-213.png https://petrovlab-stanford.squarespace.com/projects daily 0.75 2024-01-06 https://petrovlab-stanford.squarespace.com/projects/experimental-evolution-with-yeast monthly 0.5 2023-11-05 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/d864c671-df00-413c-9d8a-62d03275c4cd/experimental+evolution+png+t+wh.png https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/4d8055c1-d133-4f0d-8c76-aa1098ee3442/41586_2015_Article_BFnature14279_Fig2_HTML+copy.jpg Projects - Experimental evolution with yeast - Make it stand out Lineage trajectories from our first evolution experiment (AKA Levy-Blundell experiment) with high-throughput barcoding. Lineages are colored according to the probability that they contain an established beneficial mutation. Adapted from Levy et al, 2015. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/02744680-92fe-4821-bb61-4f43c4355fd4/fx1.jpg Projects - Experimental evolution with yeast - Make it stand out Isolation of adaptive lineages from the Levy-Blundell evolution experiment. Adapted from Venkataram et al, 2017. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/3cb0e46a-01ec-4fd3-bf24-b840b8b6fdd8/lax_61271_elife-61271-fig1-v2.jpg Projects - Experimental evolution with yeast - Make it stand out The ‘fitness-relevant modularity’ model of adaptation. Adaptive mutations may collectively (and individually) affect many phenotypes, but only a small number of phenotypes may matter to fitness in the local environment (those indicated by black squares with thick arrows pointing to fitness), whereas other phenotypes may make very small contributions to fitness (those indicated by the gray squares and thin, dashed lines leading to fitness). The contribution of each phenotype to fitness changes depending on the environment. Adapted from Kinsler at al, 2020. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/ff3f5085-a583-4d2f-a62c-6c2d96cb2941/41559_2019_993_Fig3_HTML+copy.jpg Projects - Experimental evolution with yeast - Make it stand out Pareto optimality fronts for respiration-fermentation (a) and respiration-stationary phase (b) discovered in the first-step evolution mutants. For each pair of performances, adaptive clones are plotted and colored according to their molecular basis. Each dot represents a clone. The large red dots represent the optimum phenotypes, achieving the upper limits (dashed lines) of each pair of performances. The grey curves, defined by the convex hull algorithm, represent putative Pareto optimality fronts. Adapted from Li et al, 2019. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/dfe691c4-0d7c-4dc4-b105-1c586213996a/website_figure.jpg Projects - Experimental evolution with yeast - Make it stand out An example of environmental memory common for adaptive mutants that evolved in a fluctuating environment. On the left: plotting fitness of the mutant pool in a fluctuating environment against the null hypothesis of the average of their fitness in the static environments reveals many cases of non-additivity, or vialotation from the 1:1 line. On the right: the frequency trajectory of an individual mutant (denoted by the magenta point on the left graph) shows an extreme example of non-additive fitness: for this mutant, fitness components of individual environments are opposite of those predicted by static environments. Adapted from Abreu et al, 2023. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/1699642698932-CEU5KIWGH871YCQOD1G8/image-asset.jpeg Projects - Experimental evolution with yeast - Make it stand out During wine fermentation, the composition of microbial communities changes dramatically, yet the order of succession of yeast species is highly reproducible. This makes wine fermentation an excellent model system for studying evolution in a community context. https://petrovlab-stanford.squarespace.com/projects/cancer-evolution monthly 0.5 2023-10-02 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/cdc15e60-ce75-45b0-8fa3-c03efaec577b/cancer+evolution+2+sait.png https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/3882b8ad-bcac-4b94-9455-d1d50895b85b/mish+final.jpg Projects - Cancer evolution - Make it stand out The Tuba-seq method allows us to measure the fitness of thousands of genetically distinct tumors in a single mouse in a cost-effective manner with unprecedented resolution and high precision. https://petrovlab-stanford.squarespace.com/projects/evolution-in-genomes monthly 0.5 2023-09-29 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/4c6c553c-3ffc-4f18-8cf1-593a51be05c2/evolution+in+genomes+whight.png https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/12b04eac-b2d5-4885-9e9d-a418ebd56039/Screenshot_20230127_135408_Camera+Connect.jpg Projects - Evolution in genomes - Make it stand out James, a graduate student in the lab is setting up a fly trap during a field trip in Hawaii. Photo by Bernard Kim. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/7269b3dc-afa2-4f12-813c-cd2af72dd29d/20230131_115934.jpg Projects - Evolution in genomes - Make it stand out Dmitri caught a fly during a field trip in Hawaii. Photo by Bernard Kim. https://petrovlab-stanford.squarespace.com/projects/rapid-adaptation-of-drosophila monthly 0.5 2023-11-05 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/13821f66-f087-4028-baee-6e2605b0cea5/png+white+sa.png https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/00f4d1c0-3d47-4069-8b85-036c4d7301b5/c7d06633-ef91-48ff-97b8-7c502bb9e036%2Bnew.jpg Projects - Rapid adaptation of Drosophila - Make it stand out Overview of experimental strategy, data collection, and analysis from our meosocosm system aiming to quantify adaptation on ecologically-relevant timescales. Figure modified from Rudman et al. 2022. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/282ae20d-5093-46c3-ad6c-2bfe029a437f/photo_5366102582113718827_y.jpg Projects - Rapid adaptation of Drosophila - Make it stand out Schmidt lab PhD student, Skyler Berardi, maintaining replicate D. melanogaster population in the outdoor mesocosm system at the University of Pennsylvania. https://petrovlab-stanford.squarespace.com/projects/evolution-in-microbiomes monthly 0.5 2023-11-05 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/553874c1-75df-4181-8ff5-9fe3d20b6188/evolution+in+contexts+t+png+wh.png https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/4dd082cb-90c6-4592-9a49-fd1c3b44e566/kakashka++3.png Projects - Evolution in microbiomes - Make it stand out The gut microbiome is a amazing system to study interplay between evolutionary and ecological dymanic of complex microbial communities. https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/dff12405-bc26-455a-8aa0-984cc3e64355/microbes.png Projects - Evolution in microbiomes - Make it stand out An example of change in microbiome dynamics after transient antibiotic exposure. A human subject had taken a course of low-dose antibiotics around day 0, which caused a drastic change in their microbiome composition. Each color represents a bacterial family. Adapted from Xue at al, 2023. https://petrovlab-stanford.squarespace.com/projects/conservation-genomics monthly 0.5 2023-09-27 https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/7c60607e-1914-4307-a8f6-7267d2155728/Conservation+genomics+png+t+wh.png https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/d227f871-aa2e-4518-9201-1365cb7e3489/DSC_0528.jpeg Projects - Conservation genomics - Make it stand out photo by Katie Solari https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/df0cb902-bb2c-423b-b150-f8d89a3551d2/DSC_0806.jpeg Projects - Conservation genomics - Make it stand out photo by Katie Solari https://images.squarespace-cdn.com/content/v1/64dd8c893c24b555de0349fd/f904f113-648f-4f70-ad7a-954b32ff5cf6/DSC_0544.jpg Projects - Conservation genomics - Make it stand out photo by Katie Solari https://petrovlab-stanford.squarespace.com/team daily 0.75 2026-07-01 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